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M., Schulz C., et al

Eur Rev Med Pharmacol Sci (2018) 22:21539

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B.ZhouZ.LuchiniD.TrevisiE.CorraM

10.1016/S0006-2952(03)00504-5 52

Activation of FXR in dendritic cells, macrophages, and natural killer T (NKT) cells suppresses the NF-B and NLRP3 inflammasome pathways, thereby attenuating the secretion of pro-inflammatory cytokines (e.g., TNF-, IL-6, and IL-1) while promoting the release of the anti-inflammatory mediator IL-10